Redefining Perineural Invasion: Integration of Biology With Clinical Outcome
نویسندگان
چکیده
منابع مشابه
Current research in perineural invasion of cholangiocarcinoma
BACKGROUND Perineural invasion is a common path for cholangiocarcinoma (CCA) metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It is often an early event in a disease that is commonly diagnosed in advanced stages, and thus it could offer a timely therapeutic and diagnostic target if better understood. This article systematically reviews the progress of CC...
متن کاملPrognosis and Progression of ESCC Patients with Perineural Invasion
Perineural invasion (PNI) has been recognized as a poor prognostic factor in several malignancies, but the definition and pathogenesis of PNI in esophageal squamous cell carcinoma (ESCC) remains to be defined. PNI was evaluated by H&E staining and S100 immunohistochemistry. The predictive value of PNI in the prognosis of ESCC patients was analyzed. PNI was evaluated in vitro and in vivo. A tota...
متن کامل[Management of basal cell carcinoma with perineural invasion].
The presence of perineural invasion in skin tumors constitutes a major risk factor for local recurrence.1-3 Perineural invasion is not a common finding in basal cell carcinomas, with an estimated incidence that, depending on the series, varies between 0.17%2 and 3.8%.4 The frequency is higher in more aggressive histological subtypes and in recurrent tumors.1,2,4,5 The patient was a 69-year-old ...
متن کاملPerineural Invasion in Squamous Cell Carcinoma of the Oral Cavity: Histology, Tumor Stage, and Outcome.
OBJECTIVES/HYPOTHESIS To analyze the impact of different types of perineural invasion (PNI) in squamous cell carcinoma (SCC) of the oral cavity on overall survival and recurrence rate, with a special focus on histologic subtypes and tumor stage. STUDY DESIGN Retrospective case-control study with clinicopathological analysis. METHODS Seventeen patients who received primary surgical treatment...
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A TV series from the 1970s, ‘‘The Six Million Dollar Man,’’ imagines a former astronaut with bionic implants and superhuman strength acting as a secret agent for the government. Such enhancement of human abilities with artificial components (all at a reasonable price tag) might resonate with some of today’s scientists who are working on a more modest goal of augmenting the properties of cells a...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2018
ISSN: 1476-5586
DOI: 10.1016/j.neo.2018.04.005